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Nanocarriers Based Colon Targeting : Design, Development, Mechanism and Case Studies
Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments.Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges.Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects.This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems.Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms.Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting.Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein–peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities.Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system.Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.
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Selling Schweinfurt : Targeting Assessment and Marketing in the Air Campaign Against German Industry
A common theme of airpower histories is that the Combined Bomber Offensive was the proving ground for a post-war independent air force.Whether or not the United States Strategic Air Forces (USAAF) could perform to the hype of its interwar doctrine, Allied commanders based their rival approaches to victory in Europe on their differing views of independent airpower.However, there is an essential, yet overlooked facet to this story: commanders' convictions alone could not hold sway within the War Department, much less at the politically and bureaucratically charged meetings of the Combined Chiefs of Staff.The air commanders pressed their staffs for decision-quality assessments and photographic evidence to sell their arguments and project their progress.They needed informed targeting plans and objective post-raid reports as well as an air-intelligence enterprise to mature all-too-quickly out of interwar neglect.What they received--and Brian Vlaun explains--was a collision of organizational interests and leadership personalities that shaped Ira Eaker's command of the Eighth Air Force in 1943, the tumultuous air campaign over Germany, and the path of the post-war U.S.Air Force. As a result of the author's research through thousands of declassified files, Selling Schweinfurt examines the relationships between air-intelligence organizations and key decision-makers.His analysis spans from pre-war planning and doctrine development, through the Eighth Air Force's independent air campaign, and culminates with the formation of the United States Strategic Air Forces and its 1944 pre-invasion preparations.This book concludes that military organizations, if left unchecked, may adopt symbols and exaggerate claims to justify their own preferences and market their ideas in ways that mask their optimistic assumptions.In the case of the air campaign against Germany, both the four-engine bomber and specialized targets--like Schweinfurt's ball bearings--served as symbols and powerful marketing tools for the AAF and air intelligence, respectively.
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Lipid Nanocarriers for Drug Targeting
Lipid Nanocarriers for Drug Targeting presents recent advances in the area of lipid nanocarriers.The book focuses on cationic lipid nanocarriers, solid lipid nanocarriers, liposomes, thermosensitive vesicles, and cubosomes, with applications in phototherapy, cosmetic and others.As the first book related to lipid nanocarriers and their direct implication in pharmaceutical nanotechnology, this important reference resource is ideal for biomaterials scientists and those working in the medical and pharmaceutical industries that want to learn more on how lipids can be used to create more effective drug delivery systems.
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Novel Therapeutic Approaches Targeting Oxidative Stress
Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis.The book begins with an introduction to oxidative stress and its significance.Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases.This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease.Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors.It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives.
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